New Treatments and Approaches in Melasma: Tranexamic Acid and Vitamin B 12

I would like to take you on a trip to the USA and share this very interesting article with all of you: New treatments and approaches in melasma published in the Dermatology Times, in which the dermatologist Dr. Desai was interviewed about new treatment approaches for melasma. He said that most of what is done in the treatment of pigment disorders and dermatology in general is “off label use”!

Want to know more about Tranexamic Acid?

⚡ If you want to know more about Tranexamic Acid and Melasma. Read this article to help you find the right product.

Summary of the interview with Dr. Desai

Hydroquinone Treatment and Azelaic Acid Treatment

  1. Gold standard: Hydroquinone treatment together with a steroid and a vitamin A for 8 to 10 weeks. This triple treatment is still the best treatment yet, but there are additional things you can do.
  2. Azelaic acid or kojic acid during breaks in hydroquinonic acid therapy: Dr. Densai uses 15 to 20% azelaic acid (prescription only) during breaks in treatment, or a product with kojic acid in combination with a chemical peeling.

New treatment approach – Tranexamic Acid

  • The treatment is carried out in addition to the treatments described above.
  • Tranexamic acid can be taken as a tablet and doesn’t have to be used as a cream. One tablet is taken twice a day with a dose of 500 mg to 1000 mg. In the USA only one tablet of 650 mg is available, so some of Dr. Desai’s patients halve the tablet and take one half in the morning and the other half in the evening.
  • This therapy must be used for 8 to 12 weeks before results become visible.
  • Tranexamic acid can also be found in cosmetic products, which is very pleasing because it will help very well with pigment spots and melasma.
  • Risk group:
    • All those who in the past suffered from severe venous thrombosis or a blood clot.
    • Tranexamic acid should not be used by pregnant women, nursing mothers or women using hormonal contraceptives.
  • Tranexamic acid may be used by anyone with melasma who doesn’t belong to the risk group described above.

Vitamin B12 and Melasma

Dr. Desai would also highly recommend taking a vitamin B12 preparation, especially for patients taking antihypertensive drugs, which can also cause pigmentation spots.
Vitamin B12 deficiency is often overlooked. Did you know that the first signs are almost always skin changes, such as pigment spots?

Glutathione Warning ⚠ as Skin Lightening

Dr. Desai warns his patients against glutathione because there is no scientific evidence that glutathione helps lighten the skin.

Time Factor for Melasma

The longer a patient struggles with melasma, the more difficult it is to treat the pigment disorder. Someone who has been suffering from melasma for the first 10 years has a better chance of success than someone who has been suffering from melasma for 20 years.

The Right Diagnosis for Melasma

Not all hyperpigmentations are really a melasma, because medication can also lead to pigmentation spots. In order to find the right treatment, you have to be sure whether it’s really a melasma.

New treatments and approaches in melasma – Dermatology Times
Tranexamic acid – Wikipedia
Vitamin B12 – Cobalamin –